You pop three pills for intense post-workout soreness, two for a pre-coffee headache, a small handful for period cramps, and suddenly you’re swinging by Duane Reade for a new bottle of Advil. Plenty of people take non-opioid analgesics — a k a everyday pain meds — without a second thought. Quite possibly, according to a slew of new studies. These pain-fighting drugs have a range of unexpected potential side effects, broken down below. Study buzz: In a study of 1,326 ibuprofen users, epidemiology professor David Kaufman and his research team found that about one in 10 people exceeded the suggested daily limit for the painkiller. “The biggest pattern was people taking too much at once,” he says. Side effects: Kaufman says gastrointestinal bleeding and heart attacks are “the two biggest concerns” with ibuprofen and other NSAIDs (nonsteroidal anti-inflammatory drugs, a group of pain-fighting meds that fall under the analgesic umbrella). The take-away: “It’s always a good idea to take as little” as possible, says Kaufman. I took my first dose of 50,000 units of vitamin (D2) this past Friday night. I am achy , depressed, nauseaus, headachespecially , and bone pain ,confusion, fatigue and weakness. You are on 3rd refill - does the bone pain get any less as you progress with therapy - have you found a way to help minimize the bone pain? I have not taken any more as I was totally fatigued. ( i had a gastric bypass ) now i am anemic, have brital bones vitamin D defincacey . The next night I was hyper and wide awake like I just had three cups of coffee. Have taken it twice and talked to my pharmacist and he told me to go back to my doctor. That is more than enough, that is what the pharmacist told me. I'd rather take smaller doses over a longer period of time than take the mega dose 50,000 Units with potentially life threatening side effects. I was prescribed 50,000 units once a week for 12 weeks. Thanks so much for any advice you can give.~ Capitola : ) Vitamin D3 (Cholecalciferol) is a dietary supplement that is used to treat vitamin D deficiency. Thanks Hi, I just took my first dose of vitamin d2 50,000, on Sunday. I have had absolutely no appetite whatsoever, that really scares me i'm dropping weight rapidily & already suffer from anorexia nervosa. I am finding every muscle & bone in my body hurting to the extreme. So I need to know how long will the Vit D stay in my system. Now, almost 1 week after my first dose, my heart rate is settling down. My doctor started me on 50,000IU Vitamin D3 about six years ago for severe Vitamin D deficiency. This would happen everytime I tried again to take it. I experience adrenalin rush symptoms along with a little shakiness and insomnia. After I calmed down all was fine and I was able to relax. It is also used with calcium to maintain bone strength. I haven't slept in days & feel like a complete zombie. I also noticed as I am force feeding myself my food is getting stuck in my throat as if my throat is closing up. I feel more alert and in a better mood since taking the vit D, but I am a little cautious about the 2nd dose as well. He said he had never heard of such a thing happening, but he switched me to Vitamin D2 anyway. However once I fell asleep, I stayed asleep until I woke up abruptly feeling like I couldn't catch my breath and my heart pounding... Now at 4 days later I just feel achy, a little nauseated, some stomach upset/cramps. This medicine is available both over-the-counter (OTC) and with your doctor's prescription. I've taken my second dose of 50,000 vit D3 and after taking the first dose last Friday I had no appetite later that night. Neck pain, vertigo, can't remember things,getting angry at just anything. I did not have the same side effect with the D2, but of course I was not happy about taking it, as the body does not absorb it and use it as easily as the D3. I am finding myself a little scared to take the 2nd dose this friday night... Vitamin D3 supplements have rarely produced adverse events in clinical trials. I noticed the same thing the following week but I force myself to eat. I felt the same lose of appetite a- I just took my first 50,000 unit dose of the stuff now, I feel a little hyper. Though I am not sure how it will go, as my level as of may was 18 now it's likely lower then that. I had an appointment at Mayo Clinic about a year later with a rheumatologist. I told her about the D3 incident and that my doctor had switched me to D2. You can view the side effect profile if Vitamin D3 here: https:// you for commenting in on my question. I am achy , depressed, nauseaus, headachespecially , and bone pain ,confusion, fatigue and weakness. I have awaken at night and tossed and turned and finally went back to sleep but on other websites I notice people complain of insomnia. So hopefully things will go fine, however could likely use help with answers down the road. When she heard I had been trying to take 50,000 IU of the D3 at one time, she said it was perfectly logical that I would hurt and be achy with that big of a dose. My doctor did not say anything about me taking calcium however now I am thinking I need to make sure I also have plenty of calcium in my system if I'm taking all this Vitamin D. The pharmacist and drs office claim there shouldn't be side effects but to stop taking the med and see if there is a difference I hope this loss of appetite goes away as my vit d level was 9 I took and second dose last Friday and then I got sick aches and pains in the whole body',shortness of breath, headaches dry mouth very tired all the time. I don't remember exactly how she described why the achiness occurred. But I think she said that the big dose of D3 was too much for my system, and it was pulling calcium from my bones - or something along those lines. Can you buy viagra over the counter Where to buy zoloft Blood and urine tests may be needed to check for unwanted effects. Some possible warning signs of serious side effects that can occur during treatment with. Celebrex arthritis drug safety study surprises heart experts. By Mary Brophy Marcus Updated on November 14, 2016 / AM / CBS News SAM-e supplement for depression, side effects, dosage 100 or 200 mg tablets Is it safe to take more than 400 mg? by Ray Sahelian, M. D. author of Mind Boosters Natural Supplements that Enhance Your Mood, Memory, and Mind Laura Candelaria is a family nurse practitioner and assistant professor of nursing and nutritional science. Her experience includes neonatal and pediatric intensive-care, women's oncology, gynecology, obstetrics, lactation, nutrition and infertility. She has been published in "Nursing Spectrum," "Newsday" and on various websites. View Full Profile Taking 800 mg of Ibuprofen may cause gastrointestinal effects. Symptoms include nausea, heartburn, constipation, bloating, flatulence and diarrhea. Taking your medication with food may help decrease side effects. Ibuprofen and other NSAIDs can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation, states Ibuprofen may also contribute to the development of gastric ulcers, which may be painful and cause bleeding. SAM-e is a powerful natural mood elevator and can be used to treat depression or used in those who have low mood. If you take too much you can get anxiety and insomnia. S-adenosylmethionine is made from the amino acid methionine and ATP. SAMe is a methyl donor involved in the making of dozens of important compounds in the body. This nutrient has been available by prescription in Europe for many years as an antidepressant and has been available over the counter in the US since about 1996. I have personally taken SAM-e just to see what it would do, and it is quite a powerful mood lifter. 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