Its primary function is preventing the absorption of fats from the human diet by acting as a lipase inhibitor, thereby reducing caloric intake. It is intended for use in conjunction with a healthcare provider-supervised reduced-calorie diet. The effectiveness of orlistat in promoting weight loss is definite but modest. Pooled data from clinical trials suggest that people given orlistat in addition to lifestyle modifications, such as diet and exercise, lose about 2–3 kilograms (4.4–6.6 lb) more than those not taking the drug over the course of a year. Orlistat also modestly reduces blood pressure and appears to prevent the onset of type 2 diabetes, whether from the weight loss itself or other effects. It reduces the incidence of diabetes type II in people who are obese around the same amount that lifestyle changes do. Benefits aside, however, orlistat is notorious for its gastrointestinal side effects (sometimes referred to as treatment effects), which can include steatorrhea (oily, loose stools). 120 mg TID show no additional benefit OTC (Alli): Up to 60 mg PO q8hr with each fat containing meal Only effective as an adjunct to caloric restriction, increased physical activity, and behavioral modification Also see Administration and Cautions (drug interaction overview) Flatulence Fatty/oily stool Increased defecation Fecal incontinence Nausea Vomiting Reduced absorption of fat soluble vitamins and beta-carotene Liver failure Oxalate nephropathy Leukocytoclastic vasculitis If a meal is missed or contains no fat, dose should be omitted Daily fat intake (30% of calories), carbohydrate, and protein should be evenly distributed over 3 main meals Note: Multivitamin supplement (including vit A, D, E, K) is recommended Postmarketing reports of severe liver injury with hepatocellular necrosis or acute hepatic failure with some cases resulting in liver transplant or death History of hyperoxaluria or calcium oxalate nephrolithiasis; cases of oxalate nephrolithiasis and oxalate nephropathy with renal failure have been reported Substantial weight loss can increase risk of cholelithiasis Exclude organic causes of obesisty (eg, hypothyroidism), before prescribing therapy May increase gastrointestinal events when taking a diet high on fat ( Pregnancy Category: X; weight loss offers no potential benefit to a pregnant woman and may result in fetal harm; a minimum weight gain, and no weight loss, is currently recommended for all pregnant women, including those who are already overweight or obese Lactation: Not recommended; not known if orlistat is distributed in breast milk Take with each fat-containing meal (during or up to 1 hr after the meal) The patient should be on a nutritionally balanced, reduced-calorie diet that contains ~30% of calories from fat Daily intake of fat, carbohydrate, and protein should be distributed over 3 main meals If a meal is occasionally missed or contains no fat, omit the orlistat dose The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. Levitra vs sildenafil Zoloft medication side effects Sildenafil and tamsulosin XENICAL prescription and dosage sizes information for physicians and. Contraindications. Antagonizes cyclosporine give dose 3hrs after Xenical. XENICAL orlistat is a lipase inhibitor for obesity management that acts by. XENICAL is contraindicated in patients with chronic malabsorption syndrome or. Find patient medical information for Xenical Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. This medication is used with a doctor-approved exercise, behavior change, and reduced-calorie diet program to help you lose weight. It is used by certain overweight people, such as those who are obese or have weight-related medical problems. Taking orlistat can also help keep you from gaining back weight you have lost. Losing weight and keeping it off can lessen the many health risks that come with obesity, including heart disease, diabetes, high blood pressure, and a shorter life. Dietary fats need to be broken down into smaller pieces before the body can absorb them. Orlistat works by blocking the enzyme that breaks down fats in your diet. This undigested fat then passes out of your body in your bowel movement. Xenical will return your slim figure quickly and effectively There are many ways to lose weight, however, not all of them are fast. The drug is intended for long-term monitoring of body weight, as well as for preventing weight gain. Xenical is the first prescription drug that blocks the absorption of fats Xenical acts solely in the intestine. If you don’t like waiting for a long time till you see first desired results, then you are recommended to use medical drugs, which are intended to help you become slim and beautiful in a quick and safe way. The drug is used to prevent the emergence of obesity-associated risk factors, such as: hypercholesterolemia, violation of glucose tolerance, hyperinsulinemia, hypertension. It is not absorbed into the blood, blocks the enzyme lipase, which breaks down fats. Xenical is intended for the long-term therapy combined with a low-calorie diet in obese patients, as well as in overweight people. In this regard, unsplit fats cannot pass through the intestinal wall and are excreted from the body together with feces. Xenical is recommended to be taken three times a day with each main meal. It is necessary to know the mechanism of Xenical’s action. The appearance of fatty stool with Xenical is a kind of marker of excessive consumption of fat and requires a correction of the diet, that is, the restriction of fat consumed with food. Xenical contraindications Xenical - Roche Canada, XENICAL - FDA Viagra dealsDoxycycline liver Orlistat is a drug designed to treat obesity. It is marketed as a prescription drug under the trade name Xenical by Roche. Orlistat is contraindicated in. Orlistat - Wikipedia. Xenical Oral Uses, Side Effects, Interactions, Pictures, Warnings.. XENICAL, INN-orlistat - European Medicines Agency - europa.eu. Criteria-for-Use Checklist for Orlistat Xenical. VHA Pharmacy Benefits. The patient has no contraindications to orlistat including hypersensitivity and with. There is no relevant indication for use of Xenical in children. 4.3 Contraindications. - Hypersensitivity to the active substance or to any of the excipients. - Chronic. Contraindications. Xenical is contraindicated in Pregnancy see Use in Specific Populations 8.1; Patients with chronic malabsorption syndrome; Patients with.