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    Initial: 50 mg q Day PO given continuously throughout menstrual cycle or given during luteal phase only May increase by 50 mg at the onset of each new menstrual cycle; no more than 150 mg q Day when administered continuously or 100 mg q Day when administered during luteal phase only 25 mg PO q Day initially; may increase by 25 mg every 2-3 days; not to exceed 200 mg q Day Alzheimer dementia related depression: Start at 12.5 mg/day and titrate every 1-2 weeks to response; not to exceed 150-200 mg Renal impairment: Dose adjustment not necessary Mild hepatic impairment (Child-Pugh 5-6): Decrease recommended starting dose and therapeutic dose by 50% Moderate-to-severe hepatic impairment (Child-Pugh 7-15): Not recommended; sertraline is extensively metabolized, and the effects in patients with moderate and severe hepatic impairment have not been studied Clinical worsening and suicide ideation may occur despite medication Use caution in patients with seizure disorders May worsen mania symptoms or precipitate mania in patients with bipolar disorder Increases risk of hyponatremia and impairment of cognitive/motor functions in the elderly Increases risk of bleeding in patients taking anticoagulants/antiplatelets concomitantly Risk of mydriasis; may trigger angle closure attack in patients with angle closure glaucoma with anatomically narrow angles without a patent iridectomy Pregnancy: Conflicting evidence regarding use of SSRIs during pregnancy and increased risk of persistent pulmonary hypertension of the newborn (see Pregnancy) In neonates exposed to SNRIs/SSRIs late in third trimester: Risk of complications such as feeding difficulties, irritability, and respiratory problems Avoid abrupt withdrawal Bone fractures reported with antidepressant therapy; consider the possibility if patient presents with bone pain, bruising, or point of tenderness Coadministration with other drugs that enhance the effects of serotonergic neurotransmission (eg, tryptophan, fenfluramine, fentanyl, 5-HT agonists, St. John’s Wort) should be undertaken with caution and avoided whenever possible due to the potential for pharmacodynamic interaction (see Contraindications) May cause false-positive urine immunoassay screening tests for benzodiazepines SSRIs and SNRIs are associated with development of SIADH; hyponatremia reported Several SSRIs (eg, fluoxetine, fluvoxamine, paroxetine, sertraline) are metabolized by CYP2D6 CYP2D6 is involved in the metabolism of approximately 20% of drugs in clinical use and displays large individual-to-individual variability in activity due to genetic polymorphisms More than 80 CYP2D6 variant alleles have been identified; however, 4 of the most prevalent alleles, CYP2D6*3, *4, *5, and *6, account for 93-97% of CYP2D6 poor metabolizers CYP2D6*4, the most common variant (~25% frequency in whites), causes a splicing defect; CYP2D6*3 (2.7% frequency) causes a frameshift mutation; and CYP3D6*5 (2.6%) is an entire deletion of the CYP2D6 gene; individuals homozygous for these alleles have no CYP2D6 activity The impact of CYP2D6 activity is further complicated in some SSRIs (eg, fluoxetine, fluvoxamine, paroxetine, sertraline) because in addition to being substrates for CYP2D6, they are also known to moderately inhibit CYP2D6 activity The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. Antidepressant medications are used to treat a variety of conditions, including depression and other mental/mood disorders. These medications can help prevent suicidal thoughts/attempts and provide other important benefits. However, a small number of people (especially people younger than 25) who take antidepressants for any condition may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts. Therefore, it is very important to talk with the doctor about the risks and benefits of antidepressant medication (especially for people younger than 25), even if treatment is not for a mental/mood condition. Tell the doctor right away if you notice worsening depression/other psychiatric conditions, unusual behavior changes (including possible suicidal thoughts/attempts), or other mental/mood changes (including new/worsening anxiety, panic attacks, trouble sleeping, irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech). Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed. Show More Sertraline is used to treat depression, panic attacks, obsessive compulsive disorder, post-traumatic stress disorder, social anxiety disorder (social phobia), and a severe form of premenstrual syndrome (premenstrual dysphoric disorder). This medication may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living.

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    Pictures of Zoloft Sertraline Hcl, drug imprint information, side effects for the patient. DESCRIPTION. ZOLOFT contains sertraline hydrochloride, an SSRI. Sertraline hydrochloride has a molecular weight of 342.7 and has the following chemical. Medscape - Depression, OCD, panic disorder, PTSD, PMDD-specific dosing for Zoloft sertraline, frequency-based adverse effects, comprehensive interactions.

    Serotonin, one of the neurotransmitters , is a brain chemical that carries nerve impulses from one nerve cell to another. Researchers think that depression and certain other mental disorders may be caused, in part, because there is not enough serotonin being released and transmitted in the brain. Like the other SSRI antidepressants, fluvoxamine (Luvox), fluoxetine (Prozac), and paroxetine (Paxil), sertraline increases the level of brain serotonin (also known as 5-HT). Increased serotonin levels in the brain may be beneficial in patients with obsessive-compulsive disorder, alcoholism, certain types of headaches, post-traumatic stress disorder (PTSD), pre-menstrual tension and mood swings, and panic disorder. Sertraline is not more or less effective than the other SSRI drugs although selected characteristics of each drug in this class may offer greater benefits in some patients. Fewer drug interactions have been reported with sertraline, however, than with other medications in the same class. The benefits of sertraline develop slowly over a period of up to four weeks. Sertraline is indicated for the treatment of: Major depressive episodes. Prevention of recurrence of major depressive episodes. Obsessive compulsive disorder (OCD) in adults and paediatric patients aged 6-17 years. Post traumatic stress disorder (PTSD) Depression and OCD Sertraline treatment should be started at a dose of 50 mg/day. Panic Disorder, PTSD, and Social Anxiety Disorder Therapy should be initiated at 25 mg/day. After one week, the dose should be increased to 50 mg once daily. This dosage regimen has been shown to reduce the frequency of early treatment emergent side effects characteristic of panic disorder. Depression, OCD, Panic Disorder, Social Anxiety Disorder and PTSD Patients not responding to a 50 mg dose may benefit from dose increases. Dose changes should be made in steps of 50 mg at intervals of at least one week, up to a maximum of 200 mg/day.

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    Sertraline 25 mg tablet Drug encyclopedia Kaiser Permanente, Zoloft Sertraline Hcl Side Effects, Interactions, Warning, Dosage.

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  5. Dec 28, 2018. Sertraline is an antidepressant used to treat depression, obsessive-compulsive disorder, panic disorder and anxiety. Learn about side effects.

    • Sertraline Side Effects, Uses, and Dosage -.
    • Zoloft sertraline dosing, indications, interactions, adverse effects, and..
    • Zoloft Sertraline HCl Tablets/Oral Concentrate - FDA.

    Sertraline hydrochloride belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors SSRIs. Despite distinct structural. Sertraline is indicated for the treatment of Major depressive episodes. Prevention of recurrence of major depressive episodes. Panic disorder, with or without. ZOLOFT prescription and dosage sizes information for physicians and healthcare professionals. Sertraline as HCl 25mg, 50mg, 100mg; scored tabs.

     
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    This content has not been reviewed within the past year and may not represent Web MD's most up-to-date information. To find the most current information, please enter your topic of interest into our search box. 21, 2011 -- Older women with early breast cancers are more likely to live longer and less likely to have the cancer come back when they take the drug Femara (letrozole) instead of tamoxifen, a long-term follow-up study shows. At an average follow-up of more than eight years, postmenopausal women who took Femara for five years after surgery were 20% less likely to have their breast cancer return and 21% less likely to die from their breast cancer compared to postmenopausal women who took tamoxifen. Aromatase inhibitors are now generally considered the hormonal treatment first used by most postmenopausal early breast cancer patients whose tumors are fueled by estrogen, but not all women can take the drugs. The drugs work by blocking the production of aromatase, which turns the hormone androgen into estrogen in the body. But because they don't stop the ovaries from making estrogen, they are not used to treat breast cancer patients who are still ovulating. There are more than 2.6 million breast cancer survivors living in the U. About 230,000 new breast cancers are expected to be diagnosed in the U. this year and about 40,000 women will die of the disease. The new updated analysis from the previously published Breast International Group (BIG) study adds to the evidence showing that aromatase inhibitors may be a more effective treatment than tamoxifen for postmenopausal women with estrogen-dependent tumors. Femara vs Tamoxifen Comparison - Efficacy of First-Line Letrozole Versus Tamoxifen as a Function of. What are the Side Effects of Aromatase Inhibitors Susan G. Komen®
     
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